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 induced by stress and jasmonic acid._files/transparent.gif) |
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 induced by stress and jasmonic acid._files/http_--pubs.acs.org-images-acspubs.jpg)
Chemical and biological
characterization of cinnamic acid derivatives from cell cultures of
lavender (Lavandula officinalis) induced by stress and jasmonic
acid.
Nitzsche A, Tokalov SV, Gutzeit HO,
Ludwig-Muller J.
Institut fur Botanik and Institut fur
Zoologie, Technische Universitat Dresden, D-01062 Dresden,
Germany.
Cell cultures of lavender (Lavandula officinalis) were
analyzed for the metabolite profile under normal growth conditions and
under stress as well as after jasmonic acid treatment. The main compound
synthesized was rosmarinic acid, which was also secreted into the
culture medium. Different solvent extraction methods at different pH
values altered the profile slightly. Anoxic stress induced the synthesis
of a cinnamic acid derivative, which was identified as caffeic acid by
gas chromatography-mass spectrometry. Caffeic acid was also induced
after treatment of the cell cultures with jasmonic acid. Although the
antioxidative activity of both compounds, rosmarinic acid and caffeic
acid, was confirmed in an assay using 2,2-diphenyl-1-picrylhydrazyl
(DPPH), it was demonstrated that both substances have a low cytotoxic
potential in vitro using acute myeloid leukemia (HL-60) cells. The
potential of the system for finding new bioactive compounds is
discussed.
PMID: 15137835 [PubMed - indexed for MEDLINE]
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