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Cytotoxicity of lavender
oil and its major components to human skin
cells.
Prashar A, Locke IC, Evans
CS.
School of Biosciences, University of Westminster, London,
UK.
Lavender (Lavandula angustifolia) oil, chiefly composed of
linalyl acetate (51%) and linalool (35%), is considered to be one of the
mildest of known plant essential oils and has a history in wound
healing. Concerns are building about the potential for irritant or
allergenic skin reactions with the use of lavender oil. This study has
demonstrated that lavender oil is cytotoxic to human skin cells in vitro
(endothelial cells and fibroblasts) at a concentration of 0.25% (v/v) in
all cell types tested (HMEC-1, HNDF and 153BR). The major components of
the oil, linalyl acetate and linalool, were also assayed under similar
conditions for their cytotoxicity. The activity of linalool reflected
that of the whole oil, indicating that linalool may be the active
component of lavender oil. Linalyl acetate cytotoxicity was higher than
that of the oil itself, suggesting suppression of its activity by an
unknown factor in the oil. Membrane damage is proposed as the possible
mechanism of action.
PMID: 15144499 [PubMed - indexed for
MEDLINE]
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