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Further labdane and
kaurane diterpenoids and other constituents from Plectranthus
fruticosus.
Gaspar-Marques C, Simoes MF, Rodriguez
B.
Faculdade de Farmacia da Universidade de Lisboa, Centro de
Estudos de Ciencias Farmaceuticas, Avenida das Forcas Armadas, 1649-019
Lisbon, Portugal.
Eight new diterpenoids, one labdane and seven
kaurane derivatives, and a new aromadendrane-type sesquiterpenoid have
been isolated from the most polar chromatographic fractions of an
acetone extract of Plectranthus fruticosus. The structures of the new
compounds (1-9) were established mainly by 1D and 2D NMR studies and by
some chemical transformations. Compounds 6 and 8 were characterized as
their methyl ester derivatives (13 and 14, respectively). Most of the
isolated compounds and some of their derivatives were tested as
antimicrobial agents, but only 19 showed moderate inhibitory activity
against Staphylococcus aureus.
PMID: 15104491 [PubMed - indexed
for MEDLINE]
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