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Staminane- and
isopimarane-type diterpenes from Orthosiphon stamineus of Taiwan and
their nitric oxide inhibitory activity.
Nguyen MT,
Awale S, Tezuka Y, Chien-Hsiung C, Kadota S.
Institute of
Natural Medicine, Toyama Medical and Pharmaceutical University,
2630-Sugitani, Toyama 930-0194, Japan.
From the MeOH extract of
Taiwanese Orthosiphon stamineus, two new staminane-type diterpenes,
staminols C (1) and D (2), and three new isopimarane-type diterpenes,
orthosiphonone C (3) and D (4) and 14-deoxo-14-O-acetylorthosiphol Y
(5), have been isolated together with 16 known diterpenes, orthosiphols
A, B, D, K, M, N, O, X, and Y, nororthosiphonolide A, neoorthosiphol B,
orthosiphonone A, secoorthosiphols B and C, 3-O-deacetylorthosiphol I,
and 2-O-deacetylorthosiphol J. Their structures were determined on the
basis of the spectroscopic data. All the newly isolated diterpenes
exhibited dose-dependent inhibition of nitric oxide (NO) production in
lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells, and
2-O-deacetylorthosiphonone A showed the most potent activity, with an
IC(50) value of 35.0 microM, comparable to that of the positive control
N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 35.7 microM).
PMID:
15104497 [PubMed - indexed for MEDLINE]
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