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Wound healing property of
ethanolic extract of leaves of Hyptis suaveolens with supportive role of
antioxidant enzymes.
Shirwaikar A, Shenoy R, Udupa
AL, Udupa SL, Shetty S.
Department of Pharmacognosy, College
of Pharmaceutical Sciences, Manipal 576119, India.
annieshirwaikar@yahoo.com
Ethanolic extract of leaves of Hyptis
suaveolens was evaluated for its wound healing activity in
ether-anaesthetized Wistar rats at two different doses (400 and 800
mg/kg) using incision, excision, and dead space wound model. Significant
increase in skin breaking strength, granuloma breaking strength, wound
contraction, hydroxyproline content and dry granuloma weight and
decrease in epithelization period was observed. A supportive study made
on granuloma tissue to estimate the levels of catalase and superoxide
dismutase recorded a significant increase in the level of these
antioxidant enzymes. Granuloma tissue was subjected to histopathological
examination to determine the pattern of lay-down for collagen using Van
Gieson and Masson Trichrome stains. Enhanced wound healing activity may
be due to free radical scavenging action of the plant and enhanced level
of antioxidant enzymes in granuloma tissue. Better collagenation may be
because of improved antioxidant studies.
PMID: 15267154 [PubMed -
indexed for MEDLINE]
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